The hottest infusion packaging market will show th

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Infusion packaging market will show "three pillars"

editor's note: China's infusion packaging market has always been dominated by glass bottles. In recent years, soft plastic infusion bags have gradually sprung up. When people think that this form of infusion packaging will become the mainstream, the popularity of another new type of infusion packaging - BOPP bottles has made the infusion packaging market a third of the world. According to experts' analysis, BOPP infusion bottles have huge development space. At present, some enterprises in China have seized business opportunities and are trying to engage in the R & D and production of BOPP infusion bottles

with the localization of China's BOPP large infusion bottle production equipment and its supporting sterilization and filling equipment, the unified pattern of China's large infusion glass bottle packaging is rapidly changing. BOPP large infusion bottles are showing a strong growth momentum. By the first half of next year, the production capacity of existing and under construction BOPP bottles will exceed 1billion bottles, and BOPP bottle packaging will become the mainstream packaging form of large infusion drugs. Glass bottles, soft plastic infusion bags and hard BOPP bottles are forming a pattern of three parts of the world

first, large infusion develops rapidly.

large infusion is the fastest-growing pharmaceutical dosage form in China's pharmaceutical industry. Professor xiebaoyuan from the preparation department of Shanghai Pharmaceutical Industry Research Institute said: "At present, the global output of large-scale infusion is about 12billion bottles, and China's output is 3billion bottles, accounting for about 1/4 of the total global output. China is a well deserved large-scale infusion production country. In the past 10 years, the growth rate of China's large-scale infusion production has always been maintained at 10% - 15%, and the varieties have also developed from 30, 40 to about 120 at present, of which 76 kinds of nutritional and therapeutic infusion drugs have reached, accounting for about 50% of the total."

by the first half of 2001, China had completed the GMP certification of large infusion production enterprises. The large infusion production enterprise is the first pharmaceutical production enterprise to pass the GMP certification in China, which has laid the foundation for the healthy development of large infusion in China

at present, China's large infusion production enterprises are developing towards collectivization. There are only four or five large infusion production enterprises in the United States, more than 10 in Japan, about 20 in Europe, and more than 200 in China. Such an industry structure and enterprise scale undoubtedly have high competitive risks. Therefore, the trend of alliance and merger of large infusion production enterprises is inevitable in the next few years

second, the diversification of packaging forms

the collectivization development of large infusion enterprises helps to speed up the process of packaging plastics. Unlike glass packaging, plastic infusion packaging is mostly invested by pharmaceutical enterprises themselves to introduce equipment, which requires considerable investment. However, the plasticization of infusion packaging has become a trend of globalization. At present, the application proportion of plastic infusion packaging in Europe and America is as high as 70% - 90%. For a long time, China's large infusion packaging has been the world of glass bottles. Although Otsuka and Shanghai Baite and other enterprises produce and use plastic infusion packaging, the proportion does not exceed 5%

the main reason for this situation is that in the past, all plastic packaging production equipment and raw materials were imported from abroad, which was expensive and could not meet the domestic consumption demand

infusion plastic packaging is mainly divided into plastic bottles and plastic bags. Plastic infusion bottles are divided into PE bottles and PP bottles; PP bottles are divided into squeeze blow bottles and injection blow bottles. PE bottles are all extruded and blown bottles, which are also made by a three in one machine

plastic infusion bags are divided into PVC soft bags and non PVC soft bags. From 1999 to 2000, some listed companies and private enterprises in China spent a lot of money to introduce many non PVC infusion bags and built the largest and most modern non PVC soft bag infusion factory in Asia. However, due to the exploration of production technology and process and the high product cost, the market has not passed the lead period, and most factories are seriously under operated. In the past, PP bottle injection, drawing and blowing equipment also needed to be imported from abroad, which was expensive, which also limited the use and development

strictly speaking, the launch of China's BOPP infusion bottle market began in the second half of last year. Dongguan Jiahong machinery manufacturing company launched its own BOPP infusion bottle manufacturing equipment, which caused great repercussions in the industry. The two-step injection, drawing and blowing PP bottle production equipment launched by the company has a high degree of automation, fast production speed, stable quality, less than half of the equipment investment than the imported equipment, and good product transparency. Therefore, it is sought after by large infusion production enterprises, and has won the favor of domestic famous infusion production enterprises, including Shuanghe pharmaceutical and University of science and chemistry. In just one year or so, Jiahong has delivered more than 40 sets of equipment

at present, the BOPP infusion bottle production equipment produced by Jiahong has formed three series of products ranging from 2200 to 4500 bottles per hour. The latest model adopts Siemens' double closed-loop control system, and the reliability and stability of the equipment have been further improved

III. selection of BOPP infusion bottle production equipment

facing the trend of plastic infusion packaging, how can enterprises choose the appropriate packaging form? Is it a plastic bag or a plastic bottle? PE or PP? Is it PVC or non PVC? Is it a three in one equipment or an independent packaging and manufacturing system? Is it crowding or injection? The selection process of Hunan Jinjian Pharmaceutical Co., Ltd. is representative. An Maofa, chief engineer of the company, said, "considering the problems of the production process and product cost of plastic soft bags, we decided to choose PP plastic bottles. The requirements for equipment and products are: (1) the product has good transparency, the bottle wall is uniform, and the structure is reasonable, because the penetration, elongation and deformation also increase, and good transparency is a good selling point; (2) The shrinkage and deformation should be small under the damp heat sterilization condition of 115 ℃ and 35 minutes; The mouth of the bottle should be flat, the inner and outer covers should be closely matched, and the sealing should be tight and regular. The outer cover is easy to open, and the rubber pad and inner cover can't puncture and drop debris; (3) It can automate continuous production, minimize manual operations, and minimize the possibility of errors and pollution; The equipment shall be controlled by PLC (microcomputer) as far as possible, with man-machine operation interface and optical electromechanical integration; (4) Under the condition of meeting the above requirements, domestic equipment and raw materials shall be used as much as possible to reduce project investment. According to the above conditions, the results we choose are: (1) good transparency, the injection drawing and blowing molding process is preferred, and the extrusion blowing production process and equipment are excluded; (2) To meet the damp heat sterilization at 115 ℃ for 35 minutes, PP is preferred and PE is excluded; (3) It can be produced automatically and continuously, eliminating the indigenous equipment for manual blank feeding. Therefore, we chose the equipment of Dongguan Jiahong. Supporting equipment and raw materials are also important

raw materials, sterilization equipment and filling equipment have a significant impact on the development of BOPP infusion bottles. Shandong Xinhua Medical Devices Co., Ltd. specially developed the sterilization system for PP plastic infusion bottles, and explored a set of methods and experience to deal with the problems in practice, which has a strong guiding significance for pharmaceutical enterprises that have newly installed equipment. Raw materials are another important factor determining product performance and cost. At present, the raw materials used in the production of BOPP infusion bottles are mainly from Japan, South Korea and Taiwan. Among them, the special material of PP infusion bottle of Korean Xiaoxing company has passed the USP certification of the United States, which is safe, reliable, high transparency, low stress, easy to process, and the price is also reasonable. It has been used with domestic equipment and has achieved good results

IV. market prospect

the rapid rise of BOPP bottles is related to the support of national policies. The State encourages pharmaceutical enterprises to develop new packaging, and there are corresponding preferential policies in terms of taxation. In addition, at present, the vicious competition among Chinese glass bottled infusion enterprises is very serious, and the enterprises are unprofitable. Therefore, they hope to turn around through packaging. All these have contributed to the sudden rise of BOPP bottles in the field of large infusion. Mr. guweijun, Deputy Secretary General of China Medical Equipment Engineering Association and director of Beijing jiahuate Consulting Service Co., Ltd., is a senior expert in the field of infusion packaging. He admitted that a year ago, he did not pay much attention to the application of BOPP bottles in infusion, but from the first half of this year, he suddenly found that large infusion enterprises have launched BOPP bottle production lines. He believes that BOPP infusion bottles have great development potential and will have a development cycle of at least five years

Mr. He Ruiyun, assistant general manager of Anhui Shuanghe Pharmaceutical Co., Ltd., said, "BOPP infusion bottles have developed rapidly. When we first contacted Jiahong, their BOPP bottles were not mature enough in many aspects such as production technology, hygiene and stability. Shuanghe unreservedly provided Jiahong with improvement suggestions. We are also very pleased to see that the BOPP infusion bottle equipment has become so mature."

Cai Rong and Jin Hong from Shanghai Institute of pharmaceutical packaging materials testing and Zhejiang Institute of drug control, who are responsible for drafting and formulating the infusion packaging standards for BOPP bottles, believe that the relatively centralized production equipment and technology of BOPP bottles is conducive to the formulation and implementation of national standards

Professor Xie is the initial advocate of BOPP infusion bottles. He is very optimistic about the development of BOPP bottles in China, and believes that it is a product in line with China's national conditions. It can be directly sent to local municipal waste collection points or community retail stores. It is a good product that Chinese people can do well and afford. In the future, we should further improve the automation of equipment, reduce energy consumption, and further develop soft bottle conveying

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